The gut microbiota contributes to the pathogenesis of anorexia nervosa in humans and mice

By Yong Fan, et al.: Complete Post through this link…

ngd- Not only interesting in itself, but as a potential model for investigaing the microbiome and a variety of humn diseases and conditions…

In conclusion, the present multi-omics study uncovers profound and complex disruptions of the gut microbiota in individuals with AN, with functional implications and altered serum metabolites. These compounds may act via the blood circulation or via gut-microbiota-brain neuronal signalling pathways affecting brain regulation of appetite, emotions and behaviour.

FMT from human AN donors to GF mice under energy-restricted feeding resulted in lower body weight gain and a number of changes in expression of hypothalamic and adipose tissue genes involved in controlling behaviour and energy homoeostasis. The combination of multi-omics and in vivo experiments complement our causal inference analyses to allow the identification of specific bacterial metabolites that potentially mediate human host AN traits.

Our findings lend support to the hypothesis that a severely disrupted intestinal microbiota contributes to some of the stages in the pathogenesis of AN.

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