GnRH replacement rescues cognition in Down syndrome

By MARIA MANFREDI-LOZANO: For Complete Post, Click Here…

ngd-this is interesting because the hormone is the same in mumans as it is in mice, so a small study is a useful tool to see if delivery of the hormone would produce actual effects. Apparently, it does. This makes it feasible to do a larger study…

CONCLUSION

The maintenance of the GnRH system appears to play a developmental role in brain maturation and higher functions. Pulsatile GnRH therapy holds promise to improve cognitive deficits in DS, paving the way for future clinical trials.

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