Novel Oral Antidepressant Shows Rapid Symptom Improvement

by Kristen Monaco: For Complete Post, click here…

A 2-week oral treatment for major depressive disorder was both safe and effective, according to the phase III WATERFALL study.

Compared with placebo, adults treated with zuranolone, an investigational neuroactive steroid and GABA type A receptor-positive allosteric modulator, saw a significant improvement in depressive symptoms by day 15, reported Anita H. Clayton, MD, of the University of Virginia School of Medicine in Charlottesville.

And by day 42, those who had received zuranolone were able to maintain this significant improvement in depression, Clayton reported in a poster presentation at the Psych Congress, held virtually and in San Antonio.

“Rapid onset of improvement in depressive symptoms was observed starting at day 3 and continuing through day 42,” she noted.

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