Perturbations in Gut Microbiota Composition in Psychiatric Disorders

By Viktoriya L. Nikolova, et. al.: For Complete Post, click here…

Key Points

Question  Do psychiatric disorders present with distinct or shared gut microbial alterations?

Findings  This review and meta-analysis of 59 case-control studies found that gut microbiota perturbations were associated with a transdiagnostic pattern with a depletion of certain anti-inflammatory butyrate-producing bacteria and an enrichment of pro-inflammatory bacteria in depression, bipolar disorder, schizophrenia, and anxiety.

Meaning  These findings are in line with genetic and inflammatory marker studies and support the transdiagnostic dimensional model of psychiatric disorders by highlighting the gut microbiota as an additional dimensional component.

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