Brain-first versus body-first Parkinson’s disease: a multimodal imaging case-control study

By Jacob Horsager, et al: For Entire Post, Go Here…

ngd- Interesting, if dense. so I did some editing. My grandfather developed Parkinson’s from the Spanish Flu…

Parkinson’s disease is characterized by the presence of abnormal aggregates, which may propagate from cell-to-cell. However, it remains uncertain where the initial aggregates originate.

We have hypothesized that Parkinson’s disease comprises two subtypes.

A brain-first (top-down) type, where pathology initially arises in the brain with secondary spreading to the peripheral autonomic nervous system; and a body-first (bottom-up) type, where the pathology originates in the enteric (ngd-say, the gut) or peripheral autonomic nervous system and then spreads to the brain.

We also hypothesized that isolated REM sleep behaviour disorder (iRBD) is a prodromal phenotype for the body-first type.

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