By Anita Slomski, MA: For More Info, Go Here…
Asingle ketamine infusion in individuals with cocaine use disorder, coupled with a mindfulness behavioral modification program, promoted abstinence and reduced the risk of relapse, reported a trial in the American Journal of Psychiatry.
The 55 cocaine-dependent individuals were randomly assigned to receive a 40-minute infusion of ketamine or midazolam (control group) during a 5-day inpatient stay. Midazolam has no known effect on cocaine dependence. All participants began a mindfulness-based relapse prevention (MBRP) program in the hospital, which continued in 4 weekly outpatient sessions.
During the last 2 weeks of the 5-week trial, 48.2% of the ketamine group were abstinent compared with 10.7% of the midazolam group. The ketamine group was 53% less likely to drop out of the study or relapse compared with the midazolam group.
Ketamine may help patients gain more benefit from behavioral interventions by reducing cravings, increasing motivation, and dampening reactivity to high-risk situations, the authors note.