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Summary: Rodent study reveals noise-induced hearing loss is associated with elevated expression of proinflammatory cytokines and microglia activation in the primary auditory cortex. Pharmacologically depleting microglia helps prevent tinnitus in mice with noise-induced hearing loss.
Inflammation in a sound-processing region of the brain mediates ringing in the ears in mice that have noise-induced hearing loss, according to a study publishing June 18 in the open-access journal PLOS Biology by Shaowen Bao of the University of Arizona, and colleagues.
Hearing loss is a widespread condition that affects approximately 500 million individuals and is a major risk factor for tinnitus — the perception of noise or ringing in the ears. Recent studies indicate that hearing loss causes inflammation — the immune system’s response to injury and infection — in the auditory pathway. But its contribution to hearing loss-related conditions such as tinnitus is still poorly understood. To address this gap in knowledge, Bao and his colleagues examined neuroinflammation — inflammation that affects the nervous system — in the auditory cortex of the brain following noise-induced hearing loss, and its role in tinnitus, in rodent models.
Moreover, the researchers found that pharmacological blockade of TNF-α or depletion of microglia prevented tinnitus in mice with noise-induced hearing loss. According to the authors, the findings suggest that neuroinflammation may be a therapeutic target for treating tinnitus and other hearing loss-related disorders.