How Effective Is Intranasal Esketamine, Really?

by Kristen Monaco: For More Info, Go Here…

“It’s not kooky, but it does have some risks” — and not all patients improve.

Esketamine nasal spray (Spravato) was effective for alleviating symptoms of treatment-resistant depression when added to a standard antidepressant, but clinicians should be cautious with it, researchers said here.

In a phase III trial, 197 patients with moderate to severe treatment-resistant depression on an antidepressant were randomized to receive 56 mg (or up to 84 mg if well-tolerated) of esketamine nasal spray or placebo twice weekly.


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