Bipolar disorder can be a debilitating disease. Dealing with this illness is quite difficult for patients, family, and friends. The manic phases can profoundly disrupt people’s quality of life. The cost is another reason for concern, as patients can be hospitalized for days until their symptoms are well controlled. After discharge there is a high risk of relapse, so careful observation is important to prevent rehospitalizations. But what if a simple supplement could help manage these serious flare-ups?
Bipolar disorder and gut health
There is growing evidence that mood disorders may be related to overall inflammation and to changes in the microbiome, the bacteria that live in our digestive tract. We have learned that probiotics may help improve a variety of health conditions, in part due to an anti-inflammatory effect.
Researchers from Johns Hopkins University School of Medicine designed an interesting study to determine if probiotics could help people discharged from the hospital after a manic flare-up avoid rehospitalization. The study randomized 66 patients with bipolar disorder who were hospitalized for mania and divided them into two groups of 33 patients. They gave a probiotic combination of Lactobacillus and Bifidobacterium species to one group and a placebo to the second group. They asked all patients to continue taking their regular medications for bipolar disorder and followed them for a total of 24 weeks. Before the start of the study, the researchers identified which patients had higher markers of inflammation (that is, people with more overall inflammation in the body).
What this study on probiotics and mania showed
The results were striking. The rates of rehospitalization were 51.1% in the placebo group and 24.2% in the group who took probiotics. On average, the reduction in readmission was 74% lower in the probiotic combination compared with the placebo arm of the study. The most significant finding was an almost 90% reduction of hospitalization in the group with the highest inflammation score who took probiotics. Additionally, patients who took probiotics and were rehospitalized stayed in the hospital on average 2.8 days, compared with 8.3 days for those taking placebo.